Thursday, September 10, 2026

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The Cancer News

Resistance to KRAS Inhibitors Is Multilayered, and Lineage Plasticity Deserves More Attention

Cancer Education · Research

Resistance to KRAS Inhibitors Is Multilayered, and Lineage Plasticity Deserves More Attention

Resistance to KRAS inhibitors should be understood as three distinct categories, primary/intrinsic, adaptive/non-genetic, and acquired/genetic, each with different mechanisms and different implications for how to sequence or combine therapy.

September 8, 2026

By Konstantin Dragnev, MD

Research · Cancer Education · Perspectives

Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors

Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors

by Ruta Rao, MD

Research · Cancer Education · Perspectives

Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target

Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target

by Benjamin Herzberg, MD

Top Stories

Cancer Education · Research

Early Relapse DLBCL: A Case-Based Guide to CAR T-Cell Referral, Product Selection, and Post-CAR-T Sequencing

September 7, 2026

Research · Cancer Education

Castleman Disease: Redefining the Spectrum Between "One Lymph Node" and "Many"

September 4, 2026

Research · Cancer Education

HIF-2 Alpha Inhibition in Kidney Cancer: From Adjuvant Belzutifan to the Post-Immunotherapy Setting

September 3, 2026

Cancer Education · Research · Perspectives

The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation

September 1, 2026

Cancer Education · Research · Perspectives

Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?

August 31, 2026

Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation

Research · Cancer Education · Perspectives

Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation

Kidney Cancer: Conflicting Adjuvant Immunotherapy Data and a Real Option for Non-Clear Cell Disease

Research · Cancer Education

Kidney Cancer: Conflicting Adjuvant Immunotherapy Data and a Real Option for Non-Clear Cell Disease

Gastrointestinal Cancer Updates From the Best of GI Oncology 2026

Cancer Education · Research

Gastrointestinal Cancer Updates From the Best of GI Oncology 2026

Tarlatamab for Small Cell Lung Cancer: How DLL3-Targeted Therapy Works

Cancer Education · Research

Tarlatamab for Small Cell Lung Cancer: How DLL3-Targeted Therapy Works

Cancer Education

EGFR Resistance Is Genuinely Heterogeneous, and That Should Change How We Study New Drugs

2026-09-03

Daraxonrasib and the RAS(ON) Revolution in Pancreatic Cancer Treatment

2026-09-02

How to Treat Mantle Cell Lymphoma in 2026

2026-09-02

KSHV-Associated Multicentric Castleman Disease: A Distinct Diagnosis With Distinct Treatment Considerations

2026-08-31

Research

AL Amyloidosis, POEMS Syndrome, and Extramedullary Myeloma: Diagnosis Still Lags, But Treatment Options Are Expanding Fast

2026-08-27

Colorectal Cancer: Exercise Pays for Itself, Aspirin's Role Stays Murky, and Some Patients Can Stop Immunotherapy Early

2026-08-24

Rethinking Frontline Therapy in Leukemia: Why Lower-Intensity Regimens Are Gaining Ground in AML, MDS, and ALL

2026-08-20

A New Antibody-Drug Conjugate and a Biomarker Reality Check for Small Cell Lung Cancer

2026-08-16

Health Equity

CAR-T's Real Toxicity Is Delay

2026-06-18

Why a Child's Zip Code May Be Their Most Important Cancer Prognostic Factor

2026-06-16

"I Think of Myself as a Plumber": The Engineer Trying to Fix Global Diagnostic Inequity

2026-06-10

Where You Live Matters: How Neighborhood Conditions Shape Cancer Outcomes and Survival Disparities

2026-04-01

Perspectives

Small Cell Lung Cancer in 2026: Tarlatamab Changes the Arc, and a New Wave of ADCs Is Coming

2026-07-16

ASCO 2026: Expert Commentary on the SUCCESSOR-2 Trial in Relapsed/Refractory Multiple Myeloma

2026-06-13

ASCO 2026: Sunvozertinib & Selpercatinib in Lung Cancer

2026-06-13

Sarcoma Treatment in 2026: From Gerald Ford’s Drugs to Trabectedin and Pembrolizumab

2026-06-11

Health Policy

Community Health Needs Assessment in Janakpurdham Sub-Metropolitan City, Madhesh Province, Nepal

2026-08-03

Rural Cancer Care and the Dollar Sign on Your Diagnosis

2026-06-25

What Does Oncology Have to Do With Advocacy, Anyway?

2026-06-05

Asking Because We Care: Why SOGI Data Is Essential to Equitable Cancer Care

2026-06-04

Resources for Cancer Patients

Soy and Breast Cancer: Is It Safe to Eat Tofu?

2026-06-12

Header image for article “The Hidden Role of Physical Therapy in Breast Cancer Survivorship,” featuring Dr. Rebecca Miller and a pink breast cancer ribbon.

The Hidden Role of Physical Therapy in Breast Cancer Survivorship

2025-10-16

Breast Cancer 101 title graphic on pink background with Binaytara icon.

Breast Cancer 101

2025-10-02

Blue header graphic with title "Prostate Cancer 101"

Prostate Cancer 101

2025-08-22

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